Welcome To Karachi deals with two friends, Arshad Warsi (Shammi Thakur) and Jackky Bhagnani (Kedar Patel). Jackky is desperate to go to US but is unable to do so as every time his visa gets rejected. Then, Arshad comes as a saviour for his friend and convinces him that he would take Jackky to America on a boat without any visa issues. However, the actual fun begins when the duo end up reaching Karachi in Pakistan and eventually, get into the hands of Taliban who plan to use them for terrorism. Then follows a series of comedies as Arshad and Jackky try to escape the clutches of Taliban and Pakistan as a whole. To know whether they are able to get free or end up being at the mercy of the neighbouring nation, you have to watch the movie.